The National Biosafety Laboratory BSL-4 unit is a positive pressurize suit unit and consist of three rooms. The BSL-4 unit is equipped with the standard laboratory equipment and a 56-cage individually ventilated animal cages system for small animals (mice, quail and hamster) and small volume ultracentrifuge (up to 1Mg).

Broad spectra of methods are used, such as virus isolation, neutralization test, serological test (for diagnostic purposes and development), molecular tests (PCRs, sequencing and whole genome sequencing of RG4 viruses). The BSL-4 laboratory has capacity to perform antiviral compound testing, disinfectant testing, to conduct vaccine studies, in vitro and in vivo virus isolation studies, to perform virus stability studies, produce and develop in-house diagnostic assays such immunofluorescent slides containing the whole virus and produce diagnostic polyclonal mouse/rabbit/chicken sera.